Wednesday, September 08, 2004

The Cytoplasmic Domain

By measuring the rates of endocytosis for either the overexpressed receptor, or that of other endogenous receptors, we were able to show that the endocytosis of identical receptors could be saturated, but a complete lack of competition exists between the transferrin receptor (TfR), the low-density lipoprotein receptor, and the epidermal growth factor receptor. And my left ear resembles a speckled warbler.

9 comments:

ElTigris said...

reverse the polarity dammnit

The Moody Minstrel said...

Seven is also red.

Vulgarius said...

Yeah that airplane glue just isnt what it used to be.

Don Snabulus said...

And that reversed polarity airplane glue is also red...what say you, DewKid?

DewKid said...

I would recognize the subject anywhere: my postdoctoral thesis... I was caught a bit by surprise seeing it here, I'll have to admit!

I remember there was a guy in my lab that was trying to determine the structure of the cytoplasmic domain (fondly called "tails" in our field) by using a technique called circular dichroism (or CD for short). He looked at two different constructs of the Transferrin receptor: the normal one, and a mutant that was known to escape the normal process of endocytosis. He found, in fact, that the normal had a structure known as a beta-turn, and the mutant did not, an interesting finding.

When preparing for a talk to the local scientists, he asked me to help him come up with a provocative title. I suggested "A CD of two tails".

DewKid said...

he he, he he.

I said, mutant.

Don Snabulus said...

That was a Dickens of a good name. ;)

The Moody Minstrel said...

I still think you should have named it Fred.

ElTigris said...

a dao dao gaboinger.... a tale of two boings... dem markers... tail draggers all... *gaobiing gaknopp gaboing*
mutant ... *snarf* .... pinky we are going to take over the world....